轉(zhuǎn)錄因子SOX10抗體 |
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產(chǎn)品名稱 ： 轉(zhuǎn)錄因子SOX10抗體
產(chǎn)品類別 ： IVD診斷抗體原料
品 牌 ： GenomeMe
貨 號 ： IHC010
規(guī) 格 ： 0.1ml/1ml
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詳細(xì)信息 |
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形 態(tài) ：
產(chǎn)品說明 ：
背景描述Description：
SRY(性別決定區(qū)Y)-框10(Sox-10)，又稱轉(zhuǎn)錄因子SOx-10，是調(diào)節(jié)胚胎發(fā)育和黑素細(xì)胞系細(xì)胞分化的核轉(zhuǎn)錄因子。SOX-10在神經(jīng)纖維瘤和神經(jīng)鞘瘤中廣泛表達(dá)，SOX-10基因突變與Waardenburg-Shah和Waardenburg-Hirschspung病有關(guān)。抗SOX-10抗體被證明對常規(guī)的、紡錘形和促纖維增生性黑色素瘤敏感，并被用于檢測前哨淋巴結(jié)中的轉(zhuǎn)移性黑色素瘤和淋巴結(jié)包膜痣。
SRY (Sex Determining Region Y)-Box 10 (SOX-10), also known as transcription factor SOX-10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX-10 is diffusely expressed in neurofibromas and schwannomas, and mutations in the SOX-10 gene are linked to Waardenburg-Shah and Waardenburg-Hirschsprung disease. Anti-SOX-10 has been shown to be sensitive for conventional, spindled, and desmoplastic melanoma, and has been used to detect metastatic melanoma and nodal capsular nevus in sentinel lymph nodes.
Specifications：
Clone IHC010
Source Mouse Monoclonal
Positive Control Melanoma, Skin Melanocytes
Dilution Range 1:50-1:200
參考文獻(xiàn)References：
Pingault V, et al. Nat Genet. 1998; 18:171-3.
Bondurand N, et al. Hum Mol Genet. 2000; 8:1785-9.
Kelsch RN. BioEssays. 2006; 28:788.
Nonaka D, et al. Am J Surg Pathol. 2008; 32:1291-8.
Chorny JA, et al. Am J Dermatopathol. 2002; 24:309-12.
Robson A, et al. Histopathology. 2001; 38:135-40.
Longacre T, et al. Am J Surg Pathol. 1996; 20:1489-500.
Ramos-Herberth FI, et al. J Cutan Pathol. 2010; 37:944–52.
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