全國(guó)服務(wù)熱線：020-8555-7146
配對(duì)盒基因8抗體/PAX8 Antibody |
|
|
產(chǎn)品名稱(chēng) ： 配對(duì)盒基因8抗體/PAX8 Antibody
產(chǎn)品類(lèi)別 ： IVD診斷抗體原料
品 牌 ： GenomeMe
貨 號(hào) ： IHC008
規(guī) 格 ： 0.1ml/1ml
|
|
詳細(xì)信息 |
|
|
純化方式 ：
緩 沖 液 ：
應(yīng)用說(shuō)明 ：
形 態(tài) ：
產(chǎn)品說(shuō)明 ：
背景描述Description：
Pax-8是(PAX)轉(zhuǎn)錄因子家族的一員，是早期發(fā)育過(guò)程中的關(guān)鍵調(diào)節(jié)因子。該蛋白參與甲狀腺濾泡細(xì)胞的發(fā)育和甲狀腺特異基因的表達(dá)，PAX-8基因突變與甲狀腺濾泡癌、不典型甲狀腺腺瘤和甲狀腺發(fā)育不全有關(guān)。PAX-8蛋白在單純性卵巢包涵體囊腫和輸卵管非纖毛黏膜細(xì)胞中表達(dá)，而在正常卵巢表面上皮細(xì)胞中不表達(dá)。Pax-8在正常肺和肺癌組織中也不表達(dá)。有報(bào)道PAX-8的表達(dá)與腎癌、腎母細(xì)胞瘤和精原細(xì)胞瘤有關(guān)，并表明PAX-8可作為診斷腎上皮性腫瘤、卵巢癌和鑒別診斷肺癌和頸部腫瘤的有用標(biāo)記物?？筆AX-8抗體可用于確定膀胱、肺和乳腺的卵巢微乳頭狀癌的原發(fā)部位，當(dāng)與一組器官特異性標(biāo)記物(如尿蛋白原、乳腺球蛋白和TTF-1)聯(lián)合使用時(shí)，抗PAX-8可用于確定卵巢浸潤(rùn)性微乳頭狀癌的原發(fā)部位。
PAX-8 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. This protein plays a role in development of thyroid follicular cells and the expression of thyroid-specific genes, with mutations in the PAX-8 gene linked to thyroid follicular carcinomas, atypical thyroid adenomas, and thyroid dysgenesis. The PAX-8 protein is expressed in simple ovarian inclusion cysts and non-ciliated mucosal cells of the fallopian tubes, but is absent from normal ovarian surface epithelial cells. PAX-8 is also not expressed in normal lung or lung carcinomas. Reports have associated PAX-8 expression with renal carcinoma, nephroblastoma, and seminoma, and have indicated PAX-8 as a useful marker for renal epithelial tumors, ovarian cancer, and for differential diagnoses in lung and neck tumors. Anti-PAX-8 can be useful in determining the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast, when used in adjunct with a panel of organ-specific markers such as uroplakin, mammaglobin, and TTF-1.
Specifications：
Clone IHC008
Source Mouse Monoclonal
Positive Control Ovarian Carcinoma (Non-Mucinous Carcinoma), Thyroid Carcinoma, Renal Cell Carcinoma
Dilution Range 1:50-1:200
參考文獻(xiàn)References：
Tong GX, et al. Mod Pathol. 2009; 22:1218-27.
Nonaka D, et al. Mod Pathol. 2008; 21:192-200.
Tamara L, et al. Am J Surg Pathol. 2009; 33:1037-41.
Nikiforova MN, et al. Am J Surg Pathol. 2002; 26:1016-23.
Nonaka D, et al. Am J Surg Pathol. 2008; 32:1566-71.
Marques AR, et al. J Clin Endocrinol Metab. 2002; 87:3947-52.
Tina DP, et al. J Biol Chem. 2003; 278:3395-3402.
Bowen NJ, et al. Gynecol Oncol. 2007; 104:331-7.
Zhang P, et al. Pathol Int. 2006; 56:240-245.
|
|
| {返回} | |
| |||||||||||
