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神經(jīng)生長(zhǎng)因子受體抗體/Nerve Growth Factor Receptor (NGFR) Antibody |
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產(chǎn)品名稱 ： 神經(jīng)生長(zhǎng)因子受體抗體/Nerve Growth Factor Receptor (NGFR) Antibody
產(chǎn)品類別 ： IVD診斷抗體原料
品 牌 ： GenomeMe
貨 號(hào) ： IHC637
規(guī) 格 ： 0.1ml/1ml
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詳細(xì)信息 |
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背景描述Description：
神經(jīng)生長(zhǎng)因子受體(NerveGrowthFactor Receptor，NGFR)又稱p75、P-75NTR或CD271，是腫瘤壞死因子受體家族中的一種神經(jīng)營(yíng)養(yǎng)因子受體。NGFR主要表達(dá)于雪旺細(xì)胞和神經(jīng)元，以及其他一些非神經(jīng)細(xì)胞類型，在中樞和周圍神經(jīng)系統(tǒng)發(fā)育過程中發(fā)揮調(diào)節(jié)神經(jīng)元生長(zhǎng)、遷移、分化和細(xì)胞死亡的作用。神經(jīng)生長(zhǎng)因子受體也在黑素細(xì)胞、黑色素瘤、神經(jīng)母細(xì)胞瘤、嗜鉻細(xì)胞瘤、神經(jīng)纖維瘤、神經(jīng)化痣(C型黑素細(xì)胞)及其他神經(jīng)嵴細(xì)胞或腫瘤衍生物中表達(dá)。NGFR可能是前列腺癌和尿路上皮癌的腫瘤抑制因子，抗神經(jīng)生長(zhǎng)因子受體(anti-nervegrowthfactorreceptor，NGFR)常與S100結(jié)合使用，以輔助診斷促結(jié)締組織增生性和神經(jīng)營(yíng)養(yǎng)性惡性黑色素瘤?？筃GFR抗體標(biāo)記乳腺導(dǎo)管肌上皮細(xì)胞和乳腺導(dǎo)管小葉內(nèi)成纖維細(xì)胞，有助于乳腺癌的診斷。
Nerve Growth Factor Receptor (NGFR), also known as p75, P-75NTR or CD271, is a neurotrophin receptor belonging to the tumor necrosis factor receptor family. NGFR is expressed mainly in Schwann cells and neurons, as well as a number of other non-neuronal cell types, and functions during central and peripheral nervous system development to regulate neuronal growth, migration, differentiation, and cell death. Nerve Growth Factor Receptor is also expressed in melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurofibromas, neurotized nevi (type C melanocytes), and other neural crest cell or tumor derivatives. It has been suggested that NGFR may act as a tumor suppressor indicated in prostate and urothelial cancer, and Anti-Nerve Growth Factor Receptor (NGFR) is often used in adjunct with S100, to aid in the diagnosis of desmoplastic and neurotrophic malignant melanomas. Anti-NGFR is also useful as an aid in the diagnosis of breast malignancy, as the antibody labels the myoepithelial cells of breast ducts and intralobular fibroblasts of breast ducts.
Specifications
Clone IHC637
Source Mouse Monoclonal
Positive Control Breast
Dilution Range 1:50-1:200
參考文獻(xiàn)References：
Radfar A, et al. Am J Dermatopathol. 2006; 28:162-7.
Kaplan DR, et al. Curr Opin Cell Biol. 1997; 9:213-21.
Bunone G, et al. Oncogene. 1997; 14:1463-70.
Kanik AB, et al. J Cutan Pathol. 1996; 23:205-10.
Laskin WB, et al. Hum Pathol. 2000; 31:1230-41.
Lewis Kelso R, et al. Dermatol Surg. 2006; 32:177-83.
Liang Y, et al. J Invest Dermatol. 1998; 111:114-8.
Liang Y, et al. J Cutan Pathol. 1998; 25:189-98.
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