錯配修復蛋白2抗體/MSH2 Antibody |
|
|
產(chǎn)品名稱 ： 錯配修復蛋白2抗體/MSH2 Antibody
產(chǎn)品類別 ： IVD診斷抗體原料
品 牌 ： GenomeMe
貨 號 ： IHC410
規(guī) 格 ： 0.1ml/1ml
|
|
詳細信息 |
|
|
純化方式 ：
緩 沖 液 ：
應用說明 ：
形 態(tài) ：
產(chǎn)品說明 ：
背景描述Description：
MutS同源物2(MSH2)是一種參與錯配修復途徑的蛋白。該蛋白通常與遺傳性非息肉病性結(jié)直腸癌有關，該基因的突變與散發(fā)性結(jié)直腸癌的發(fā)生有關。將抗MSH2與抗MSH6、MLH1和PMS2的抗體配對在IHC面板中時，可優(yōu)化抗MSH2的使用。報告顯示，抗MSH2抗體可用于檢測許多正常和腫瘤組織中的MSH2蛋白。
MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumors that are microsatellite-unstable.
Specifications：
Clone IHC410
Source Mouse Monoclonal
Positive Control Colon Mucosa, Colon Carcinoma
Dilution Range 1:50-1:200
參考文獻References：
Pal T, et al. Cancer. 2008; 113:733-42.
Brueckl WM, et al. Anticancer Res. 2003; 23:1773-8.
Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
Renkonen E, et al. J Clin Oncol. 2003; 21:3629-37.
Hoedema R, et al. Am Surg. 2003; 69:387-92.
Christensen M, et al. Cancer. 2002; 95:2422-30.
Wahlberg SS, et al. Cancer Res. 2002; 62:3485-92.
Lanza G, et al. Mod Pathol. 2002; 15:741-9.
Thibodeau SN, et al. Cancer Res 1996; 56:4836-40.
|
|
| {返回} | |
| |||||||||||
