IV型膠原蛋白抗體/Collagen Type IV Antibody |
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產(chǎn)品名稱 ： IV型膠原蛋白抗體/Collagen Type IV Antibody
產(chǎn)品類別 ： IVD診斷抗體原料
品 牌 ： GenomeMe
貨 號 ： IHC549
規(guī) 格 ： 0.1ml/1ml
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詳細信息 |
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純化方式 ：
緩 沖 液 ：
應用說明 ：
形 態(tài) ：
產(chǎn)品說明 ：
背景描述Description：
Ⅳ型膠原是基底膜的主要成分，可作為觀察基底膜是否存在和檢查其結構的標志。除上皮基底層外，抗Ⅳ型膠原染色間充質成分。它有助于鑒別軟組織腫瘤，包括神經(jīng)鞘瘤和平滑肌瘤?？耿粜湍z原抗體在分化良好、惡性后常與這些組織發(fā)生反應。在研究腫瘤的血管成分、血管外皮細胞瘤、血管肉瘤和上皮樣血管內皮瘤時，抗Ⅳ型膠原蛋白的應用比非特異性的銀網(wǎng)狀染色法產(chǎn)生更可靠的結果。
Collagen Type IV is a primary component in the basal lamina that is used as a marker to observe the presence of the lamina and examine its structure. In addition to the epithelial basal lamina, Anti-Collagen Type IV stains mesenchymal components. It is useful for identifying soft tissue cancers including schwannomas and leiomyomas. Anti-Collagen Type IV frequently reacts with these tissues after becoming well-differentiated and malignant. The use of Anti-Collagen Type IV produces more reliable results than non-specific silver reticulum stains when investigating the vascular elements of neoplasms, hemangiopericytoma, angiosarcoma and epithelioid hemangioendothelioma.
Specifications：
Clone IHC549
Source Mouse Monoclonal
Positive Control Lung, Muscle
Dilution Range 1:50-1:200
參考文獻References:
Gould VE, et al. Pathol Annul. 1976; 11:353-86.
McArdle JP, et al. Int J Cancer. 1984: 34:633-8.
Sakr WA, et al. Hum Pathol. 1987; 18:1043-50.
Barsky SH, et al. Am J Surg Pathol. 1983; 7:667-77.
De Iorio P, et al. Anticancer Res. 2001; 21:1395-9.
Maatta M, et al. J Histochem Cytochem. 2001; 49:711-26.
Schmehl K, et al. Int J Colorectal Dis. 2000; 15:39-48.
Felix A, et al. Hum Pathol. 1999; 30:964-9.
Damiani S, et al. Virchows Arch. 1999; 434:227-34.
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