精氨酸酶1抗體/Arginase-1 Antibody |
|
產(chǎn)品名稱 : 精氨酸酶1抗體/Arginase-1 Antibody
產(chǎn)品類別 : IVD診斷抗體
品 牌 : GenomeMe
貨 號 : IHC400-100
規(guī) 格 : 0.1ml/1ml
|
|
詳細(xì)信息 |
|
純化方式 :
緩 沖 液 :
應(yīng)用說明 :
形 態(tài) :
產(chǎn)品說明 :
背景描述Description:
精氨酸酶-1(Arginase-1,Arginase-1)是由ARG1基因編碼的一種胞漿金屬酶,主要在肝細(xì)胞中表達(dá),催化精氨酸水解為鳥氨酸和尿素,在尿素循環(huán)中起關(guān)鍵作用。精氨酸血癥是一種遺傳的常染色體隱性遺傳病,其特點(diǎn)是血液中精氨酸和氨的積累。抗精氨酸酶-1對肝細(xì)胞具有很高的特異性,是一種敏感、特異的良、惡性肝腫瘤標(biāo)志物。
Arginase-1, encoded by the ARG1 gene, is a cytosolic metalloenzyme expressed predominantly in hepatocytes which plays a key role in the urea cycle by catalyzing the hydrolysis of arginine to ornithine and urea. Argininemia is an inherited autosomal recessive disorder characterized by a buildup of arginine and ammonia in the blood. Anti-Arginase-1 is highly specific for hepatocytes, and is therefore a sensitive and specific marker of benign and malignant hepatic tumors.
Specifications:
Clone IHC400
Source Mouse Monoclonal
Positive Control Liver
Dilution Range 1:50-1:200
參考文獻(xiàn)References:
1. Morris SM Jr. Br J Pharmacol. 2009; 157:922–930.
2. Uchino T, et al. Human Genetics. 2009; 96:255–60.
3. Yan BC, et al. Am J Surg Pathol. 2010; 34:1147-1154.
|
|
{返回} |