膜粘連蛋白A1/Annexin A1抗體 |
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產(chǎn)品名稱 : 膜粘連蛋白A1/Annexin A1抗體
產(chǎn)品類別 : 抗體
品 牌 : GenomeMe
貨 號 : IHC512
規(guī) 格 : 0.1ml/1ml
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詳細(xì)信息 |
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純化方式 :
緩 沖 液 :
應(yīng)用說明 :
形 態(tài) :
產(chǎn)品說明 :
背景描述Description:
膜聯(lián)蛋白A1(AnnexinA1,ANXA1)是一種膜蛋白,通過控制炎癥、前列腺素和白三烯介質(zhì)的生物合成,在先天免疫和適應(yīng)性免疫中發(fā)揮作用。在毛細(xì)胞白血病患者的所有樣本中,97%的樣本中該靶蛋白過表達(dá),而在其他B細(xì)胞淋巴瘤中未見該靶蛋白的表達(dá)。ANXA1高表達(dá)常與晚期食管和食管胃交界區(qū)腺癌有關(guān),也與晚期和轉(zhuǎn)移性疾病有關(guān)。
Annexin A1 (ANXA1) is a membrane protein that plays a role in innate and adaptive immunity by controlling the biosynthesis of inflammation, prostaglandins, and leukotriene mediators. This target is overexpressed in 97% of all samples from patients with with hairy cell leukemia, and is absent in other B-cell lymphomas. High ANXA1 expression is frequently associated with advanced stage esophageal and esophagogastric junction adenocarcinoma, and is also linked to advanced and metastatic disease states.
Specifications:
Clone IHC512
Source Mouse Monoclonal
Positive Control Hairy Cell Leukemia
Dilution Range 1:50-1:200
參考文獻(xiàn)References:
1. Tiacci E, et al. N Eng J Med. 2011; 364:2305-2315.
2. Wang K, et al. Clin Cancer Res. 2006; 12:4598-4604.
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