產(chǎn)品說明 ：
產(chǎn)品貨號(hào)Reference: CAN-P-320
檢測方法Kit Type: Competitive ELISA
規(guī)格Kit Size: 96-well break-apart microplate
靈敏度Sensitivity: 0.11 ng/mL
檢測樣本Sample Type: Human serum / 50 μL
檢測范圍Calibrator Range: 0.15–20 ng/mL
檢測時(shí)間Total Assay Time: 75 minutes
背景介紹：
類固醇17α-羥孕酮是由腎上腺皮質(zhì)和性腺產(chǎn)生的。17-α-OHP幾乎沒有孕激素活性，它是11-脫氧皮質(zhì)醇(CPD-S)的直接前體，CPD-S是由17個(gè)α-OHP的21-羥基化反應(yīng)生成的。17-α-OHP的測定是檢測21-羥化酶活性的一個(gè)有用的間接指標(biāo)。在先天性腎上腺皮質(zhì)增生癥最常見的21-羥化酶脫氫酶中，17-羥化酶(17-?-α)分泌過多。因此，檢測17例α-OHP對(duì)CAH的早期診斷有重要價(jià)值。
The steroid 17α-hydroxyprogesterone is produced by the adrenal cortex and gonads. 17α-OHP has little progestational activity, but it is of intense clinical interest because it is the immediate precursor to 11-desoxycortisol (Cpd-S). Cpd-S is produced by the 21-hydroxylation of 17α-OHP. Measurement of 17α-OHP is a useful indirect indicator of 21-hydroxlase activity. In congenital 21-hydroxylase de? ciency, the most common variety of congenital adrenal hyperplasia (CAH), 17α-OHP is secreted in abundant excess. Measurement of 17α-OHP is therefore valuable in the initial diagnosis of CAH.
