產(chǎn)品說明 ：
產(chǎn)品貨號(hào)Reference: CAN-TE-6090
檢測方法Kit Type: Competitive LIA
規(guī)格Kit Size: 96-well break-apart microplate
靈敏度Sensitivity: 1 pg/mL
檢測樣本Sample Type: Human saliva / 100 μL
校準(zhǔn)范圍Calibrator Range: 2–800 pg/mL
檢測時(shí)間Total Assay Time: 120 minutes
背景介紹：
睪酮是一種C-19類固醇，男性是從睪丸和腎上腺皮質(zhì)分泌的，女性是從腎上腺皮質(zhì)和卵巢分泌的。睪酮也是由雄烯二酮的外周組織產(chǎn)生的，這在男性中沒有什么生理意義，但在女性中，大約有一半的循環(huán)睪酮是從這個(gè)來源產(chǎn)生的。睪酮的作用既有雄激素的作用，也有合成代謝的作用。睪酮測量主要用于男性性腺功能減退和女性高雄激素狀態(tài)的臨床評估。
大多數(shù)循環(huán)睪酮與三種蛋白質(zhì)結(jié)合：性激素結(jié)合球蛋白(44-78%)、白蛋白(20-54%)和皮質(zhì)醇結(jié)合球蛋白(少量)。只有大約2-3%的總循環(huán)睪酮仍然沒有束縛或以自由的形式。只有循環(huán)睪酮的游離部分(或非SHBG結(jié)合部分)被認(rèn)為可用于發(fā)揮其生物學(xué)作用的組織。
唾液激素測定法因其無創(chuàng)、簡便的標(biāo)本采集方法而備受推崇。唾液睪酮具有很高的臨床價(jià)值，因?yàn)樗硌獫{睪酮的百分比。許多研究表明唾液睪酮與游離或非SHBG結(jié)合的睪酮有很好的相關(guān)性。
Testosterone is a C-19 steroid secreted from the testis and the adrenal cortex in men and from the adrenal cortex and ovary in women. Testosterone is also produced by peripheral tissues from androstenedione, which is of little physiological signi? cance in men, however in women about half of circulating testosterone is derived from this origin. The action of testosterone is both androgenic and anabolic. Testosterone measurements are used mainly for clinical evaluation of hypogonadism in males and hyperandrogenic states in females.
Most of the circulating testosterone is bound to three proteins: sex hormone binding globulin (44–78%), albumin (20–54%) and cortisol binding globulin (small amount). Only about 2–3%of the total circulating testosterone remains unbound or in the free form. Only the free portion (or the non-SHBG bound fraction) of the circulating testosterone is thought to be available to tissues where it exerts its biological actions.
The salivary hormone assays are advocated for their non-invasive, easy sample collection method. Salivary testosterone is of great clinical value for it represents a ? ltered fraction of plasma testosterone and is independent of flow rate. Many studies have suggested that salivary testosterone correlates well with either free or non-SHBG bound testosterone.
注：本產(chǎn)品僅用于科研用途，不能直接用于人體或臨床診斷使用。
