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序 列 ： |
The synthetic peptide used to raise the antibody Cat. No. 251344 is selected from a sequence within the center region of human beta-arrestin 1/2. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended. |
| 分 子 式 ： |
C70H125N25O19 |
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分 子 量 ： |
1620.9 g/mol |
|
純 度 ： |
Purity > 80% by HPLC |
|
形 態(tài) ： |
Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect. |
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溶 解： |
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. |
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保存條件 ： |
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. |
| 別 名 ： |
beta-arrestin 1; beta-arrestin 2; beta-arrestin 1/2; Beta-arrestin-1/2; Beta-arrestin-1; Arrestin beta-1; ARRB1; Beta-arrestin-2; Arrestin beta-2; ARRB2 |
| 產(chǎn)品鏈接 ： |
http://www.ABBIOTEC.com/peptides/beta-arrestin-12-peptide |
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產(chǎn)品說(shuō)明 ： |
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| 產(chǎn)品描述 ： |
Beta-arrestins function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein. Beta-arrestin binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adaptor protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). This antibody recognizes beta-arrestin-1 and beta-arrestin-2. The extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. |
