|
序 列 ： |
Human: H-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-OH or H-EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ-OH |
| 分 子 式 ： |
C129H211N35O48 |
|
分 子 量 ： |
3020.33 g/mol |
|
純 度 ： |
Purity > 95% by HPLC |
|
形 態(tài) ： |
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt. |
|
溶 解： |
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. |
|
保存條件 ： |
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C. |
| 產(chǎn)品鏈接 ： |
http://www.ABBIOTEC.com/peptides/c-peptide%25252C-human |
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產(chǎn)品說(shuō)明 ： |
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| 產(chǎn)品描述 ： |
The connecting peptide, or C-peptide, is a 31-aa long peptide that connects insulin A-chain to the B-chain in the proinsulin molecule. In the insulin synthesis pathway, preproinsulin is translocated into the endoplasmic reticulum of beta cells of the pancreas with an A-chain, a C-peptide, a B-chain, and a signal sequence. After signal sequence cleavage, the C-peptide is removed from the newly formed proinsulin in the Golgi apparatus leaving the A- and B-chains bound together by disulfide bonds, forming the insulin molecule. Besides a role in assembly, folding, and processing of insulin in the ER, the C-peptide is a bioactive peptide with effects on microvascular blood flow and tissue health. Because equimolar amounts of C-peptide are stored in secretory granules of the pancreatic beta cells and eventually released in the circulation, C-peptide is a marker of insulin secretion in understanding the pathophysiology of type 1 and type 2 diabetes. |
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