| 克隆類型 ： |
Rabbit Polyclonal IgG |
|
免 疫 原 ： |
Peptide derived from human ADAM20. |
|
純化方式 ： |
Immunogen affinity purified |
|
緩 沖 液 ： |
PBS, pH 7.4(1%BSA and 0.1% Sodium azide) |
|
產(chǎn)品描述 ： |
ADAM20 was first cloned from a human testis library as a protein with homology to the fertilins (ADAMs 1, 2). ADAM20 message was seen predominantly in testis, but also at lower levels in placenta and B-cells. ADAM20 is closely related to ADAM21 (61% identical), ADAM29 (52% identical), and the testases (49-46% identical). ADAM20 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and the initial partial sequence of ADAM21 contained a non-functional catalytic site, making it tempting to speculate that ADAM20 and ADAM21 are orthologs to ADAMs 1&2. Later, a full-length ADAM21 sequence demonstrated a functional catalytic domain, but it may still be that the catalytically dead form of ADAM21 is expressed and functions as a fettilin. A member of the metalloproteinase family containing disintegrin-like domains (ADAMs) the function of ADAM20 is still poorly understood. Other ADAMs family members (ADAM10, ADAM17) have been more thoroughly studied, and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions. |
| 適用物種 ： |
Hu |
| 應用說明 ： |
WB: 1:200-1:1000 E: 1:500-1:1000 IHC: 1:200-1:1000 IF: 1:100-1:500 |
| 別 名 ： |
A disintegrin and metalloproteinase domain 20; A disintegrin and metalloproteinase domain 20 preproprotein; ADA20_HUMAN; ADAM 20; ADAM metallopeptidase domain 20; ADAM20; Disintegrin and metalloproteinase domain-containing protein 20; EC 3.4.24.; OTTHUMP00000236151. |
| 保存條件 ： |
Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted. |
| 標 記 物 ： |
PLLABS公司可供應生物素、辣根過氧化物酶、熒光素標記抗體 |
|
產(chǎn)品說明 ： |
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