| 克隆類(lèi)型 ： |
Mouse Monoclonal Antibody；Clone number：HI30 |
|
亞 型 ： |
Mouse IgG1 |
|
純化方式 ： |
Concentration：0.5 mg/ml |
|
緩 沖 液 ： |
PBS pH 7.2, 0.09% NaN3, 0.2% BSA |
|
產(chǎn)品描述 ： |
CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA), B220, and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. |
| 適用物種 ： |
Hu |
|
應(yīng)用范圍 ： |
FC |
| 應(yīng)用說(shuō)明 ： |
The amount of the reagent is suggested to be used ≤ 0.125 μg per 10^6 cells in 100 μl volume or 100 μl of whole blood. |
| 保存條件 ： |
Store at 4°C and protected from prolonged exposure to light. Do not freeze. |
| 標(biāo) 記 物 ： |
BIOT |
|
產(chǎn)品說(shuō)明 ： |
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