| 克隆類型 ： |
Mouse Monoclonal Antibody；Clone number：17F3 |
|
亞 型 ： |
Mouse IgG1 |
|
純化方式 ： |
Concentration：0.5 mg/ml |
|
緩 沖 液 ： |
PBS pH 7.2, 0.09% NaN3, 0.2% BSA |
|
產(chǎn)品描述 ： |
IL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by TH17 cells,a distinct CD4+ T cell lineage. IL-17A stimulates the production of the pro-inflammatory cytokines IL-1β, TNFα, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity . IL-17A is intimately involved in mucosal immunity against bacterial infections and has a putative role in some autoimmune disorders . IL-17A effects appear to be exerted primarily through binding to the IL-17RA.IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the ERK1/2 MAP kinase, PI3K/Akt, p38, and NF-κB pathways . Phosphorylation of some Jaks and Stats has been observed. |
| 適用物種 ： |
Mouse |
|
應(yīng)用范圍 ： |
FC |
| 應(yīng)用說明 ： |
The amount of the reagent is suggested to be used ≤ 0.25 μg /10^6 cells in 100 μl |
| 保存條件 ： |
Store at 4°C and protected from prolonged exposure to light. Do not freeze. |
| 標(biāo) 記 物 ： |
FITC |
|
產(chǎn)品說明 ： |
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