克隆類型 : |
Rat Monoclonal Antibody;Clone number:DTA-1 |
亞 型 : |
Rat IgG2b |
純化方式 : |
Concentration:0.2 mg/ml |
緩 沖 液 : |
PBS pH 7.2, 0.09% NaN3, 0.2% BSA |
產(chǎn)品描述 : |
GITR, Glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18, and AITR (in humans). It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ T regulatory (Treg) cells. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation, and abrogate the inhibitory functions of CD4+CD25+ Treg cells. In vivo activation GITR causes development of autoimmune diseases and restores the suppressed immune responses. |
適用物種 : |
Mouse |
應(yīng)用范圍 : |
FC |
應(yīng)用說(shuō)明 : |
The amount of the reagent is suggested to be used ≤ 0.25 μg /10^6 cells in 100 μl |
保存條件 : |
Store at 4°C and protected from prolonged exposure to light. Do not freeze. |
標(biāo) 記 物 : |
PE |
產(chǎn)品說(shuō)明 : |
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