| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MDM2. |
|
產(chǎn)品描述 ： |
MDM2 mediates ubiquitination of p53/TP53, leading to its degration by the proteasome. MDM2 inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding to their respective transcriptional activation domains. MDM2 also acts as an ubiquitin ligase towards itself and ARRB1, permits the nuclear export of TP53/p53, and promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. |
| 適用物種 ： |
H, M, R, Ch, Mk, Rb, GP, P, Ca, D, Hs, B |
|
應(yīng)用范圍 ： |
E, WB |
| 應(yīng)用說明 ： |
E: 1:10,000-1:20,000; WB: 1:5,000-1:10,000 |
| 別 名 ： |
MDM2; E3 ubiquitin-protein ligase Mdm2; p53-binding protein Mdm2; Oncoprotein Mdm2; Double minute 2 protein; Hdm2 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5% BSA with 0.05% sodium azide and 0.05% thimerosal. Antibody was purified by antigen-affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/mdm2-antibody-1 |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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