| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SPRYD2. |
|
產(chǎn)品描述 ： |
SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy. |
| 適用物種 ： |
H, M, R |
|
應用范圍 ： |
E, WB, IHC, IF |
| 應用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IF: 1:50-1:200; IHC: 1:100-1:500 |
| 別 名 ： |
SPRY domain-containing protein 2; cardiomyopathy-associated protein 5; CMYA5; dystrobrevin-binding protein 2; DTNBP2; TRIM76; genethonin-3; myospryn; tripartite motif-containing protein 76; C5orf10; SPRYD2 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/spryd2-antibody |
| 標 記 物 ： |
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產(chǎn)品說明 ： |
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