| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human KLOTHO. |
|
產(chǎn)品描述 ： |
KLOTHO is the systemic anti-aging hormone within the glycosidase 1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor. |
| 適用物種 ： |
H, M, R |
|
應用范圍 ： |
E, WB, IHC, IF |
| 應用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC:1:100-1:500; IF: 1:50-1:200 |
| 別 名 ： |
KL; KLOTHO |
|
形 態(tài) ： |
Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/klotho-antibody |
| 標 記 物 ： |
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產(chǎn)品說明 ： |
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