| 克隆類型 ： |
Rabbit Polyclonal Antibody |
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亞 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within human DCLK3. |
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產品描述 ： |
DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. |
| 適用物種 ： |
H, M |
|
應用范圍 ： |
E, WB, IF |
| 應用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IF: 1:100-1:500 |
| 別 名 ： |
DCLK3; Doublecortin kinase-like 3; DCK32; CLr; DCAMKL3; DCDC3C |
|
形 態(tài) ： |
Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產品鏈接 ： |
http://www.abbiotec.com/antibodies/dclk3-antibody |
| 標 記 物 ： |
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產品說明 ： |
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