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RAP80 Antibody
產(chǎn)品名稱 : RAP80 Antibody
中文名稱
產(chǎn)品類別 : 一抗
品  牌 : ABBIOTEC
貨  號(hào) : 253768
規(guī)  格 : 0.1mg
詳細(xì)信息
克隆類型 Rabbit Polyclonal Antibody
亞  型 Rabbit Ig
免  疫 原 KLH-conjugated synthetic peptide encompassing a sequence within human RAP80.
產(chǎn)品描述 RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
適用物種 H, M
應(yīng)用范圍 E, WB, IHC
應(yīng)用說(shuō)明 E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
別  名 RAP80 ; Receptor associated protein 80; Ubiquitin interaction motif-containing 1; UIMC1
形   態(tài) Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
保存條件 Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
產(chǎn)品鏈接 http://www.abbiotec.com/antibodies/rap80-antibody
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