克隆類型 : |
Rabbit Polyclonal Antibody |
亞 型 : |
Rabbit Ig |
免 疫 原 : |
KLH-conjugated synthetic peptide encompassing a sequence within human RAP80. |
產(chǎn)品描述 : |
RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist. |
適用物種 : |
H, M |
應(yīng)用范圍 : |
E, WB, IHC |
應(yīng)用說(shuō)明 : |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
別 名 : |
RAP80 ; Receptor associated protein 80; Ubiquitin interaction motif-containing 1; UIMC1 |
形 態(tài) : |
Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
保存條件 : |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
產(chǎn)品鏈接 : |
http://www.abbiotec.com/antibodies/rap80-antibody |
標(biāo) 記 物 : |
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產(chǎn)品說(shuō)明 : |
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