| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin O. |
|
產品描述 ： |
Cyclin O (CCNO) has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to intrinsec apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Suppression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. This protein was previously called UNG2 after being erroneously identified as a uracil DNA glycolase, but later identified as a cyclin protein family member. This antibody binds to the two isoforms of Cyclin O. |
| 適用物種 ： |
H, M, R |
|
應用范圍 ： |
E, WB |
| 應用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500 |
| 別 名 ： |
Cyclin O; CCNO; cyclin-O |
|
形 態(tài) ： |
Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產品鏈接 ： |
http://www.abbiotec.com/antibodies/cyclin-o-antibody |
| 標 記 物 ： |
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產品說明 ： |
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