| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human cIAP. |
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產(chǎn)品描述 ： |
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7. The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-alpha by its receptor. Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP. Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP. |
| 適用物種 ： |
H, M |
|
應(yīng)用范圍 ： |
E, WB, IHC, IF |
| 應(yīng)用說明 ： |
Cat. No. 253483 detects both c-IAP1 and c-IAP2. E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IF: 1:50-1:200 |
| 別 名 ： |
cIAP; c-IAP; Baculoviral IAP repeat-containing protein 2; c-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; IAP-2; hIAP-2; IAP2; RING finger protein 48; TNFR2-TRAF-signaling complex protein 2; BIRC2; API1; IAP2; MIHB; RNF48 |
|
形 態(tài) ： |
Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/ciap-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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