| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
mouse IgG1 |
|
免 疫 原 ： |
150 amino acid recombinant protein from N-term moiety of mouse PD-1. |
|
產(chǎn)品描述 ： |
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of “danger signals” such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE. |
| 適用物種 ： |
H, M, R |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說(shuō)明 ： |
E: 1:500-1:1,000; WB: 1:500-1:1,000; IHC: 1:100-1:500 |
| 別 名 ： |
PD-1; Programmed cell death 1; PDCD-1; CD279 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.02% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存條件 ： |
Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/pd-1-12a7d7-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說(shuō)明 ： |
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