| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
Yeast nuclear preparations. |
|
產(chǎn)品描述 ： |
Fibrillarin is a nucleolar protein involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein found in all eukaryotes and archea generally called fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a ~34kDa protein which was subsequently found to be fibrillarin. Recent studies show that knock-out of the fibrillarin gene in mice results in embryonic lethality, although mice with only one functional fibrillarin/Nop1p gene were viable. |
| 適用物種 ： |
Y, H, R |
|
應(yīng)用范圍 ： |
E, WB, IF |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:1,000; IF: 1:500 |
| 別 名 ： |
rRNA 2'-O-methyltransferase fibrillarin; U3 small nucleolar RNA-associated protein NOP1; Nucleolar protein 1; U3 snoRNA-associated protein NOP1; NOP1 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of HEPES (pH7.5), 0.01% BSA, with 50% glycerol with 0.065% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/fibrillarin-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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