| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
Purified recombinant fragment of human KLHL13 expressed in E. coli. |
|
產(chǎn)品描述 ： |
KLHL13 (Kelch-like protein 13) is a 604 amino acid long protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase. |
| 適用物種 ： |
H |
|
應(yīng)用范圍 ： |
E, WB, IHC, IF, FC |
| 應(yīng)用說明 ： |
E: 1:10000; WB: 1:500-1:2000; IF: 1:200-1:1000; IHC: 1:200-1:1000; FC: 1:200-1:400 |
| 別 名 ： |
Kelch-like protein 13; BTB and kelch domain-containing protein 2; BKLHD2; KIAA1309; KLHL13 |
|
形 態(tài) ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/klhl13-8d1-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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