| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
Purified recombinant fragment of human Pirh2 expressed in E. coli. |
|
產(chǎn)品描述 ： |
Pirh 2 (P53 induced RING-H2 protein) mediates E3-dependent ubiquitination and proteasomal degradation of proteins. Pirh2 has ubiquitin-protein ligase activity and binds to p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered together with MDM2, to act as a negative regulator of p53 function. |
| 適用物種 ： |
H, R |
|
應(yīng)用范圍 ： |
WB, IF, FC |
| 應(yīng)用說明 ： |
WB: 1:500-1:2000;
IF: 1:200-1:1000;
FC: 1:200-1:400;
|
| 別 名 ： |
RING finger and CHY zinc finger domain-containing protein 1; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger protein 199; Zinc finger protein 363; p53-induced RING-H2 protein; hPirh2; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; RCHY1 |
|
形 態(tài) ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/pirh2-1h10-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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