| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG2b |
|
免 疫 原 ： |
Purified recombinant fragment of human GATA4 expressed in E. coli. |
|
產(chǎn)品描述 ： |
GATA4 (GATA binding protein 4) is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1/2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations have been associated with cardiac septal defects. |
| 適用物種 ： |
H, M |
|
應(yīng)用范圍 ： |
WB |
| 應(yīng)用說明 ： |
WB: 1:500-1:2000;
|
| 別 名 ： |
Transcription factor GATA-4; GATA-binding factor 4; GATA4 |
|
形 態(tài) ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/gata4-6h10-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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