| 克隆類型 ： |
Mouse Monoclonal Antibody |
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亞 型 ： |
Mouse IgG1 |
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免 疫 原 ： |
Purified recombinant fragment of RSPO1 expressed in E. coli.
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產品描述 ： |
RSPO1 (R-spondin 1) is a member of the R-spondin family, a 28.9 kDa secreted activator protein. It has two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. |
| 適用物種 ： |
H |
|
應用范圍 ： |
WB |
| 應用說明 ： |
WB: 1:500-1:2000;
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| 別 名 ： |
R-spondin-1; Roof plate-specific spondin-1; hRspo1; RSPO1 |
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形 態(tài) ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 產品鏈接 ： |
http://www.abbiotec.com/antibodies/rspo1-7a6-antibody |
| 標 記 物 ： |
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產品說明 ： |
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