| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG2b |
|
免 疫 原 ： |
Purified recombinant fragment of SRC(aa10-193) expressed in E. coli. |
|
產(chǎn)品描述 ： |
c-Src (Proto-oncogene tyrosine-protein kinase Src) is a non-receptor protein tyrosine kinase. It plays pivotal roles in numerous cellular processes such as proliferation, migration and transformation. In concert with PTK2B, c-Src plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex and c-SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins by PTK2B, c-Src phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. C-Src promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. |
| 適用物種 ： |
H |
|
應(yīng)用范圍 ： |
WB |
| 應(yīng)用說明 ： |
WB: 1:500-1:2000;
|
| 別 名 ： |
SRC; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; p60-Src; c-Src; SRC1 |
|
形 態(tài) ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/src-4f1e-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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