| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG2b |
|
免 疫 原 ： |
Purified recombinant fragment of P16 expressed in E. coli. |
|
產(chǎn)品描述 ： |
CDK4I or p16-INK4 (Cyclin-dependent kinase 4 inhibitor A) is a negative regulator of the proliferation of normal cells. It is interacting strongly with CDK4 and CDK6 and by subsequently inhibiting their interaction with cyclins D and retinoblastoma protein phosphorylation. Defects in p16-INK4 are involved in tumor formation in a wide range of tissues. These defects cause cutaneous malignant melanoma 2 (CMM2), familial atypical multiple mole melanoma-pancreatic carcinoma syndrome, melanoma-astrocytoma syndrome and Li-Fraumeni syndrome. |
| 適用物種 ： |
H, R |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說明 ： |
E: 1:5,000-1:10,000; WB: 1:500-1:2,000; IHC: 1:200-1:1,000 |
| 別 名 ： |
P16; Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase inhibitor A; CDK4I; p16-INK4a; p16INK4A; p16-INK4; multiple tumor suppressor 1; MTS-1; CDKN2A; CDKN2; MTS1 |
|
形 態(tài) ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
|
產(chǎn)品文獻(xiàn) ： |
[1] Shuai Y et al. 2016. Theranostics. 6(11): 1899-917. PMID 27570559. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/p16-2d9a-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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