| 克隆類(lèi)型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG2b |
|
免 疫 原 ： |
Purified recombinant fragment of LYN expressed in E. coli. |
|
產(chǎn)品描述 ： |
Lyn (p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphorylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3. Lyn is a member of the src family of non-receptor protein tyrosine kinases, predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI). |
| 適用物種 ： |
H |
|
應(yīng)用范圍 ： |
WB |
| 應(yīng)用說(shuō)明 ： |
WB: 1:500-1:2000;
|
| 別 名 ： |
Lck/Yes-related novel protein tyrosine kinase; V-yes-1; Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; JTK8; FLJ26625 |
|
形 態(tài) ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/lyn-2h8d-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說(shuō)明 ： |
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