| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
Purified recombinant fragment of human TIMP-3 expressed in E. coli. |
|
產品描述 ： |
TIMP-3 (Tissue inhibitor of metalloproteinases 3) is a secreted extracellular matrix protein, metalloprotease inhibitor. It forms complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-3 is critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. Defects in TIMP-3 are the cause of Sorsby fundus dystrophy (SFD). SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patient’s eye within 6 months to 6 years. |
| 適用物種 ： |
H |
|
應用范圍 ： |
WB, IHC |
| 應用說明 ： |
WB: 1:500-1:2000; IHC: 1:200-1:1000
|
| 別 名 ： |
Metalloproteinase inhibitor 3; Tissue inhibitor of metalloproteinases 3; TIMP-3; Protein MIG-5; TIMP3 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 產品鏈接 ： |
http://www.abbiotec.com/antibodies/timp-3-antibody-1 |
| 標 記 物 ： |
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產品說明 ： |
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