| 克隆類(lèi)型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG1 |
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免 疫 原 ： |
Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. coli. |
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產(chǎn)品描述 ： |
Estrogen and progesterone receptors are members of a family transcription that are regulated by the binfing of their cognate ligands. The interaction of hormone bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrogen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. Both have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B) which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors. |
| 適用物種 ： |
H |
|
應(yīng)用范圍 ： |
WB, IHC |
| 應(yīng)用說(shuō)明 ： |
WB: 1:500-1:2000; IHC: 1:200-1:1000
|
| 別 名 ： |
Estrogen receptor; ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1; ESR1; ESR; NR3A1 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/er-alpha-2b7-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說(shuō)明 ： |
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