| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
Purified recombinant fragment of CHK1 expressed in E. coli. |
|
產品描述 ： |
CHK1 (Serine/threonine-protein kinase CHK1) is required for checkpoint-medated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. CHK1 phosphorylates Cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by Chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro. |
| 適用物種 ： |
H, M |
|
應用范圍 ： |
WB |
| 應用說明 ： |
WB: 1: 500-1: 2,000
|
| 別 名 ： |
CHEK1; CHK1; Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 產品鏈接 ： |
http://www.abbiotec.com/antibodies/chk1-2g1d-antibody |
| 標 記 物 ： |
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產品說明 ： |
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