| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
Purified recombinant fragment of human MCL-1 expressed in E. coli. |
|
產(chǎn)品描述 ： |
Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related protein and was identified as an early-induction gene product with increased expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.
|
| 適用物種 ： |
H |
|
應用范圍 ： |
WB, IHC, IF |
| 應用說明 ： |
WB: 1:500-1:2000; IHC: 1:200-1:1000; IF: 1:200-1:1000;
|
| 別 名 ： |
Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT; BCL2L3; MCL1 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/mcl-1-8c6-antibody |
| 標 記 物 ： |
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產(chǎn)品說明 ： |
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