| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
Purified recombinant fragment of human NPM expressed in E. coli. |
|
產(chǎn)品描述 ： |
Nucleophosmin (NPM) is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities . The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase. |
| 適用物種 ： |
H, Mk |
|
應(yīng)用范圍 ： |
WB, IHC, IF |
| 應(yīng)用說明 ： |
WB: 1:500-1:2000; IHC: 1:200-1:1000; IF: 1:200-1:1000 |
| 別 名 ： |
Nucleophosmin; NPM; Nucleolar phosphoprotein B23; Numatrin; Nucleolar protein NO38; NPM1; NPM |
|
形 態(tài) ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存條件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/nucleophosmin-7h10-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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