| 克隆類型 ： |
Rabbit Polyclonal Antibody, Phosphospecific Antibody |
|
亞 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Thr402 of rat PAK-1, 2, 3. Thr402 in PAK-2 corresponds to Thr423 in human PAK-1. |
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產(chǎn)品描述 ： |
Serine/threonine-protein kinase PAK-1 (PAK-1) is a protein kinase that acts on a variety of targets. PAK-1 is the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. PAK-1 is activated by CDC42 and RAC1, and is involved in dissolution of stress fibers and reorganization of focal complexes. PAK-1 is involved in regulation of microtubule biogenesis through phosphorylation of TBCB. PAK-1 activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Autophosphorylation of Thr402 has been found to be essential for activation of PAK. |
| 適用物種 ： |
B, D, H, M, R |
|
應用范圍 ： |
E, WB |
| 應用說明 ： |
E: 1:1,000; WB: 1:1,000 |
| 別 名 ： |
Serine/threonine-protein kinase PAK 1; p21-activated kinase 1; PAK-1; p65-PAK; Alpha-PAK; PAK1 |
|
形 態(tài) ： |
Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/pak-123-thr402-antibody |
| 標 記 物 ： |
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產(chǎn)品說明 ： |
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