| 克隆類型 ： |
Rabbit Polyclonal Antibody, Phosphospecific Antibody |
|
亞 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser41 of rat Gap-43. |
|
產(chǎn)品描述 ： |
GAP-43 (Growth associated protein-43, neuromodulin) is a cytoplasmic axonal membrane protein that is involved in the neuronal outgrowth and synaptic plasticity of developing and regenerating neurons . Palmitoylated GAP-43 attaches to the membrane via lipid rafts, while the unmodified form is a component of the centrosome. GAP-43 binds to calmodulin in the absence of Ca++ and functions as a substrate for PKC in the nerve growth factor (NGF) signaling pathway. Gap-43 functions as an adapter protein, binding and interacting with several molecules including PKC, PIP2, actin, calmodulin, spectrin, palmitate, synaptophysin, amyloid, and tau. A lack of GAP-43 or phosphorylation leads to severe neuronal developmental or learning disfunction. |
| 適用物種 ： |
B, D, Ck, H, M, X, Zf |
|
應(yīng)用范圍 ： |
E, WB |
| 應(yīng)用說明 ： |
E: 1:1,000; WB: 1:1,000 |
| 別 名 ： |
GAP-43; Growth-associated protein 43; Neuromodulin; Axonal membrane protein GAP-43; PP46; Neural phosphoprotein B-50; GAP43 |
|
形 態(tài) ： |
Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/gap-43-ser41-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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