| 克隆類型 ： |
Rabbit Polyclonal Antibody, Phosphospecific Antibody |
|
亞 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser368 of rat connexin 43. |
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產(chǎn)品描述 ： |
Connexin-43 (Gap junction alpha-1 protein, GJA1) forms connexons at cell gap junctions through which materials of low MW diffuse from one cell to a neighboring cell. Connexin-43 has a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Connexons are composed of a hexamer of connexins. Connexin-43 is expressed in the heart and fetal cochlear. Phosphorylation of Ser368 by PKC induces a conformational change of connexin-43 that results in a decrease in gap junction permeability. Defects in connexin-43 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD), a serious condition of cranofacial anomalies, ocular defects and sometimes deafness and cardiac abnormalities. |
| 適用物種 ： |
B, D, Ck, G, H, M, Zf |
|
應(yīng)用范圍 ： |
E, WB |
| 應(yīng)用說(shuō)明 ： |
E: 1:1,000; WB: 1:1,000 |
| 別 名 ： |
Connexin-43; Gap junction alpha-1 protein; Cx43; Gap junction 43 kDa heart protein; GJA1; GJAL |
|
形 態(tài) ： |
Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/connexin-43-ser368-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說(shuō)明 ： |
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