| 克隆類(lèi)型 ： |
Rabbit Polyclonal Antibody, Phosphospecific Antibody |
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亞 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Thr286 of human CaMK-II. |
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產(chǎn)品描述 ： |
CaM Kinase 2 alpha (CAMKII alpha) is a prominent Ser/Thr kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. A member of the NMDAR signaling complex at the excitatory synapse, it regulates NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. CAMK2a is composed of alpha, beta, gamma, and delta chains that assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. CaMK2a interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1. Phosphorylation of Thr286 produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. |
| 適用物種 ： |
H, M, X |
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應(yīng)用范圍 ： |
E, WB |
| 應(yīng)用說(shuō)明 ： |
E: 1:1,000; WB: 1:1,000 |
| 別 名 ： |
CaMK2a; Calcium/calmodulin-dependent protein kinase type II alpha chain; CaM-kinase II alpha chain; CaM kinase II subunit alpha; CaMK-II subunit alpha; CaMK-II beta; Calcium/calmodulin-dependent protein kinase type II beta chain; Calcium/calmodulin-dependent protein kinase II beta; Calcium/calmodulin-dependent protein kinase IIβ; CaM-kinase II beta chain; CaM kinase II subunit beta; CaMK-II subunit beta; CaMKIIβ; CAMK2B; CAM2; CAMKB |
|
形 態(tài) ： |
Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/camk-ii-thr286-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說(shuō)明 ： |
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