| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of mouse CD183. |
|
產(chǎn)品描述 ： |
Chemokine receptor CXCR3 (CD183) is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Binding of CXCL9, CXCL10, and CXCL11 to CD183 is able to elicit increases in intracellular Ca2++ levels and activate phosphoinositide 3-kinase and mitogen-activated protein kinase (MAPK). CD183 binds to CCL21 and is expressed in lymphoid organs and Th1 cells. CXCR3 has been implicated in the following diseases, atherosclerosis, multiple sclerosis, pulmonary fibrosis, type 1 diabetes, autoimmune myasthenia gravis, nephrotoxic nephritis, acute cardiac allograft rejection, and possibly Celiac Disease. |
| 適用物種 ： |
M, R |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說(shuō)明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
CXC-R3; CD183; C-X-C chemokine receptor type 3; CXCR-3; Interferon-inducible protein 10 receptor; IP-10 receptor; Cmkar3; CXCR3 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻(xiàn) ： |
Tsutahara K et al. 2012. Nephrology Dialysis Transplantaion. 27(10): 3799-3806. PMID#22904101 |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/cd183-rodent-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說(shuō)明 ： |
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