| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TOP2B. |
|
產(chǎn)品描述 ： |
DNA topoisomerase 2-beta (TOP2B) controls topological states of DNA by transient breakage and subsequent rejoining of DNA strands. TOP2B makes double-strand breaks. TOP2B is indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils. |
| 適用物種 ： |
H |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說明 ： |
E: 1:10,000-1:40,000; WB: 1:200-1:500 |
| 別 名 ： |
TOP2B; DNA topoisomerase 2-beta; DNA topoisomerase II, beta isozyme; TOP2B |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/top2b-antibody |
| 標 記 物 ： |
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產(chǎn)品說明 ： |
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