| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human caspase-8. |
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產(chǎn)品描述 ： |
Caspase-8 is the most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Caspase-8 forms an aggregate with FADD called death-inducing signaling complex (DISC). DISC performs caspase-8 proteolytic activation. The active dimeric enzyme is liberated from the DISC and free to activate downstream apoptotic proteases. Defects in caspase-8 are the cause of caspase-8 deficiency (CASP8D). CASP8D is a disorder resembling autoimmune lymphoproliferative syndrome (ALPS). It is characterized by lymphadenopathy, splenomegaly, and defective CD95-induced apoptosis of peripheral blood lymphocytes (PBLs). |
| 適用物種 ： |
H |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說明 ： |
E: 1:1,000-1:10,000; WB: 1:200-1:1,000; IHC: 1:50-1:200 |
| 別 名 ： |
Caspase-8; CASP-8; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; CASP8; MCH5 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/caspase-8-antibody-0 |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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