| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GAD-65. |
|
產(chǎn)品描述 ： |
65 kDa glutamic acid decarboxylase (GAD-65) catalyzes the production of GABA. In mammals, GAD exists in two isoforms encoded by two different genes - Gad1 and Gad2. These isoforms are GAD-67 and GAD-65, with molecular weights of 67 and 65 kDa, respectively. GAD-67 and GAD-65 are expressed in the brain where GABA is used as a neurotransmitter, GAD-65 is also expressed in the pancreas. Both GAD-67 and GAD-65 are targets of autoantibodies in people who later develop type 1 diabetes mellitus or latent autoimmune diabetes. Injections with GAD-65 has been shown to preserve some insulin production for 30 months in humans with type 1 diabetes. |
| 適用物種 ： |
H |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說(shuō)明 ： |
E: 1:10,000-1:50,000; WB: 1:200-1:500; IHC: 1:50-1:200 |
| 別 名 ： |
Glutamate decarboxylase 2; Glutamate decarboxylase 65 kDa isoform; 65 kDa glutamic acid decarboxylase; GAD-65; GAD2; GAD65 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/gad-65-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說(shuō)明 ： |
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