| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DDX58. |
|
產(chǎn)品描述 ： |
Probable ATP-dependent RNA helicase DDX58 (DDX58) is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, DDX58 triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). DDX58 detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). DDX58 is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. |
| 適用物種 ： |
H |
|
應(yīng)用范圍 ： |
E, WB |
| 應(yīng)用說明 ： |
E: 1:10,000-1:50,000; WB: 1:500-1:2,000 |
| 別 名 ： |
Probable ATP-dependent RNA helicase DDX58; DEAD box protein 58; Retinoic acid-inducible gene 1 protein; RIG-1; Retinoic acid-inducible gene I protein; RIG-I; DDX58 |
|
形 態(tài) ： |
Each vial contains 0.1 mL of crude serum with 0.09% sodium azide. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/ddx58-antibody |
| 標 記 物 ： |
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產(chǎn)品說明 ： |
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