| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human cyclin D 1. |
|
產(chǎn)品描述 ： |
G1/S-specific cyclin-D1 (cyclin D1) is essential for the control of the cell cycle at the G1/S (start) transition. Cyclin D1 interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Cyclin D1 interacts with FBXO4 and CDKN1B. Cyclin D1 is ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination, by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB. Defects in cyclin D1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. |
| 適用物種 ： |
H, M, R |
|
應(yīng)用范圍 ： |
E, WB |
| 應(yīng)用說明 ： |
E: 1:10,000-1:40,000; WB: 1:500-1:1,000 |
| 別 名 ： |
Cyclin D1; G1/S-specific cyclin-D1; PRAD1 oncogene; BCL-1 oncogene; BCL1; PRAD1 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/cyclin-d1-antibody-1 |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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