| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Notch 2. |
|
產(chǎn)品描述 ： |
Neurogenic locus notch homolog protein 2 (Notch 2) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), Notch 2 forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Notch 2 affects the implementation of differentiation, proliferation and apoptotic programs. Defects in Notch 2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems. |
| 適用物種 ： |
H |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說(shuō)明 ： |
E: 1:10,000-1:50,000; WB: 1:500-1:1,000; IHC: 1:100-1:500 |
| 別 名 ： |
Neurogenic locus notch homolog protein 2; Notch 2; hN2; NOTCH2 |
|
形 態(tài) ： |
Each vial contains 0.1 mL of crude serum with 0.09% sodium azide. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/notch-2-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說(shuō)明 ： |
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