| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human VDAC-1. |
|
產(chǎn)品描述 ： |
Voltage-dependent anion-selective channel protein 1 (VDAC-1) forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; whereas in the plasma membrane it is involved in cell volume regulation and apoptosis. VDAC-1 adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has weak anion selectivity whereas the closed state is cation-selective. VDAC-1 participates in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. |
| 適用物種 ： |
H |
|
應(yīng)用范圍 ： |
E, WB |
| 應(yīng)用說明 ： |
E: 1:10,000-1:50,000; WB: 1:100-1:500 |
| 別 名 ： |
Voltage-dependent anion-selective channel protein 1; VDAC-1; hVDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; VDAC1; VDAC |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻(xiàn) ： |
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| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/vdac-1-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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