| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
Bovine brain S-100B |
|
產(chǎn)品描述 ： |
S-100 protein is a 21-kDa component isolated first from the brain but later found in a wide variety of normal and neoplastic cells of mesodermal, neuroectodermal, and epithelial origins. The S-100 protein is found in 3 forms: S-100a(0), a homodimer of alpha-alpha subunits; S-100a, a heterodimer of alpha-beta subunits; and, S-100b, a homodimer of beta-beta subunits. S-100 binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction plays a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. S-100 weakly binds calcium but binds zinc with a higher affinity. Concentrations of potassium ions antagonize the binding of both divalent cations, especially calcium. |
| 適用物種 ： |
H, M, R, B |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說(shuō)明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein; S100B |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% with 0.09% sodium azide. Antibody was purified by anti-mouse IgG affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻(xiàn) ： |
Aydogan A et al. 2012. Dept of Pathology. Faculty of Veterinary Medicine. Revue Med. Vet. 163(11):536-538 |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/s-100-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說(shuō)明 ： |
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