| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of chicken pan-cadherin. |
|
產(chǎn)品描述 ： |
Cadherins are calcium dependent cell adhesion proteins. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells. Cadherins contribute to the sorting of heterogeneous cell types. N-cadherin functions during gastrulation and is required for establishment of left-right asymmetry. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway which phosphorylates beta-catenins attached to both N-cadherin and E-cadherins. |
| 適用物種 ： |
H, M, R, Rb, Ck |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
Pan-Cadherin; Cadherin; CDH; Cadherin-2; DH2; Neural cadherin; N-cadherin |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻(xiàn) ： |
Pranjal Sarma et al. 2015. Centre for Chemical Biology; CSIR-Indian Institute of Chemical Technology. Oct. 16(10): 1486–1501. PMID: 26192233. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/pan-cadherin-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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